The Potential Utilization of Membrane Chromatography for the Unfolding / Refolding of Recombinant Fusion Proteins by the Example of Insulin-Glargine Fusion Protein

Abstract

The present article is devoted to the development of a method of recombinant insulin-glargine fusion protein production by means of membrane chromatography. The possibility of ion-exchange membrane utilization for the sorption of solubilized inclusion bodies, their unfolding and subsequent protein refolding and following purification is under discussion.

References

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