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Изучение и математическое описание кинетики высвобождения доксорубицина из PLGA наночастиц in vitro
Аннотация
DOI: 10.30906/2073-8099-2020-12-4-27-37
Профиль высвобождения активного ингредиента из наночастиц является одним из важнейших параметров наносомальной лекарственной формы. Разработаны и оптимизированы методы изучения кинетики высвобождения доксорубицина из наночастиц PLGA в модельные среды in vitro. Оптимальным методом отделения наночастиц является ультрацентрифугирование, а наиболее подходящей модельной средой — 1 % водный раствор полоксамера 188. Профиль высвобождения имеет выраженный двухфазный характер и подчиняется закону диффузии Фика. Изучение кинетики высвобождения доксорубицина в плазме крови ограничено низкой стабильностью в условиях эксперимента (4 ч при 37 °C).
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