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Hypoglycemic and Antidiabetic Effects of Polysaccharide from Turnip Seeds Brassica rapa in Experimental Diabetes Mellitus

Д. Г. Абдугафурова, Д. А. Аманликова, М. Ж. Орипова, Б. Б. Корабоева, З. Н. Кузиева, Ю. И. Ощепкова

Abstract


Study of the antidiabetic and hypoglycemic activity of the BSP polysaccharide from the seeds of the turnip Brassica rapa in an alloxan-induced model of diabetes mellitus in experimental rats. The animals were divided into groups. On the second day after the induction of diabetes mellitus, the animals were intragastrically injected with the BSP polysaccharide from the seeds of the turnip Brassica rapa and inulin as a reference substance as an antidiabetic agent for the prevention and treatment of diabetes mellitus) for 14 days. On the 7th and 14th days, the animals’ blood was taken to determine the glucose content and hematological analysis. According to the results of studying the properties of acute toxicity of the BSP polysaccharide from the seeds of the turnip Brassica rapa, it was found that this substance belongs to class V compounds — practically non-toxic substances. With intragastric administration of inulin at doses of 25, 50 and 75 mg/kg and BSP polysaccharide from the seeds of the turnip Brassica rapa at doses of 10, 20 and 30 mg/kg 14 days after the induction of diabetes mellitus, the indicator was close to that of the intact group of animals (intact — 3.07 ± 0.25, inulin 2.99 — 3.14 ± 0.23, and BRP polysaccharide from the seeds of the turnip Brassica rapa 2.53 — 3.14 ± 0.20), while the indicator of the control group was 8.40 ± 0.35. During 14 days of treatment after the induction of diabetes mellitus, all blood counts and immunocompetent cells (leukocytes, erythrocytes and platelets) recovered to a normal physiological state after intragastric administration of inulin and BSP polysaccharide from Brassica rapa seeds.

DOI: 10.30906/2073-8099-2023-15-5-43-49


Keywords


Brassica rapa, polysaccharides, diabetes mellitus, alloxan

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